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In preclinical models, MTP-131 has been studied for its ability to reduce myocardial infarction damage and improve cardiac function

However, in genetically predisposed individuals, a subset of autoreactive T cells can evade these mechanisms, become activated, proliferate, and differentiate, initiating an autoimmune cascade (Fig

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The main exception to this rule is the GLP-1 class (like semaglutide, tirzepatide, or retatrutide), which may be used for longer under proper supervision since the studies and pharmacology support extended duration