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Indeed, lithium therapy of cultured cerebellar granule cells increased mRNA and protein levels of Bcl-2, and the Bcl-2/Bax protein level ratio increased by 5-fold after treatment duration for 57 days 124

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Gahl WA, Reed GF, Thoene JG, Schulman JD, Rizzo WB, Jonas AJ, Denman DW, Schlesselman JJ, Corden BJ, Schneider JA (1987) Cysteamine therapy for children with nephropathic cystinosis

Mechanisms of action: NF-B inhibition: KPV inhibits the activation of nuclear factor kappa-B (NF-B), the master regulator of the inflammatory response

Cells were subjected to SMG using a 3D Random Positioning Machine (RPM) (Chatterjee Laboratory, India), a widely adopted platform for studying gravity-dependent cellular responses under controlled laboratory settings 53