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Patients with a history of pancreatitis, medullary thyroid cancer, or multiple endocrine neoplasia type 2 should avoid semaglutide regardless of Lipo C use, as semaglutide carries a black-box warning for these conditions

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Methods: For this analysis of the multicenter CASPR study, we categorized patients into three groups: (1) those with an identified mechanism (e.g., PFO, device-detected AF within 12 months, ipsilateral 3050% ulcerated atherosclerosis or carotid web, or grade 4 aortic arch atheroma), (2) those with no identifiable mechanism despite advanced workup (ESUS-AW), and (3) those without advanced workup (ESUS-NAW)