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De Quervains tenosynovitis, according to my doctor in Halifax

These changes lead to the accumulation of damaged proteins in myocytes, thereby reducing their ability to adapt to physiological stress and increasing the risk of heart disease in old age

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They developed a photoactivatable form of the Rho GTPase RAC1, known to regulate spine dynamics through the modulation of actin polymerization (Costa et al., 2000)