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Although its pathogenesis may vary depending on geography, genetic factors, and environmental influences, hypothyroidism is often considered a chronic and ongoing health problem (Centanni et al., 2017

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doi:10.1016/S0140-6736(20)30183-5 3

For instance, it remains undefined whether Gd-IgA1 directly binds to mesangial cell receptors to activate the PPARFABP1 axis, or if indirect signals (e.g., inflammatory cytokines and complement activationhallmarks of IgA nephropathy) are required