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downregulation of inflammatory mediators, fibrosis-promoting genes, and metalloproteinases associated with tissue degradation

Specifically, berberine has been shown to mitigate liver injury induced by methotrexate, HFD, and CCl 4 through the activation of the Nrf2 pathway in rats [60,63,64]

This accumulation of iA results in deleterious effects including synaptic abnormalities 6 , long-term potentiation impairment 7,8,9 and cognitive decline 8,10,11,12,13,14,15,16,17

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