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Notably, Mn 2+ -mediated activation of the cGASSTING pathway has been widely reported to amplify the anti-tumor response to a range of immunotherapies 132,297,298,299,300,301,302,303,304,305 , as comprehensively reviewed recently by Zhang et al

Western blot (WB) results revealed a significant increase in the expression of Ki-67 and Lamin B, while the protein levels of P21, P16, and -H2AX decreased following FOXO4-DRI treatment (Figure 4A)

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