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But the compound, given twice weekly, did not help those people whose symptoms were evident for between one and three years, and no one showed significant benefits

Knockout of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1), a major hepatic glycerol-3-phosphate acyltransferase, decreased de novo DAG generation protecting mice from hepatic insulin resistance (195)