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It appeared most plausible that the density belongs to either NAC or NMT1, and using AF3 to identify potential interactions, positioning of the NACA UBA domain on a hydrophobic site of the ARF1 surface was predicted (Supplementary Fig

& Tarsounas, M

Iannuzzo et al

Deficiency of 1 -antitrypsin presents in infancy as liver disease, or in adulthood as lung disease 1 -Antitrypsin is a member of the serpin family of serine protease inhibitors, and, contrary to its name, its predominant target is macrophage-derived elastase

Collectively, by maintaining a reduced intracellular environment, GSH restrains pro-necrotic kinase activation and preserves inhibitory protease function, particularly CASP8, thereby preventing aberrant necroptotic signaling and inflammatory cell death