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However, aberrant activation of this pathway disrupts TJs, causing increased BBB leakage in CNS diseases [76, 77]

N., Doll, M., Dupre, T

Pharmacological effects (appetite suppression, delayed gastric emptying) typically resolve within 1014 days, well before absolute peptide clearance is complete

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doi: 10.3389/fnut.2025.1577369 Received 15 February 2025 Accepted 07 May 2025 Published 09 June 2025 Volume 12 - 2025 Edited by Giacomo Di Matteo, Sapienza University of Rome, Italy Reviewed by Massimo Frangiamone, Universit de Lausanne, Switzerland Tamara Hoppenbrouwers, Wageningen University and Research, Netherlands Updates Copyright 2025 Bietto, Arranz, Miralles, Gmez-Marn, Rath, Lucey and Giblin