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Additionally, ATF4 and CCAAT/enhancer-binding protein (CEBP) homologous protein (CHOP) mRNA are highly expressed, along with activated PERK pathway in VSMCs and macrophages at this stage (76) (Figure 2A)

Yang L, Zheng XL, Sun H, Zhong YJ, Wang Q, He HN, et al

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A hydrated glow can show up within a day or two, texture and tone shifts build over the first few weeks, and firming from genuine collagen remodeling is a 6 to 8 week story at the earliest and keeps deepening over 3 to 6 months

Reference 1 Literature Number: WP03