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doi: 10.3324/haematol.2013.085217 46 DufvaOPlnenPBrckOKernenMAIKlievinkJMehtonenJet al

(24) investigated plasma mtDNA levels in RA patients and found that RA patients had a high sensitivity to mtDNA copy number compared to healthy controls, and also found that plasma mtDNA concentration was significantly correlated with the Disease Activity Score-28-Erythrocyte Sedimentation Rate (DAS28-ESR), which increased with the increase of DAS28-ESR, thus it is reasonable to believe that plasma mtDNA may be an inflammatory contributor as well as a biomarker in RA

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Reduced availability of T3 and the possibility of hypothyroid-like symptoms despite normal T4 levels are caused by insufficient Se, which impairs the operation of DIO1 and DIO2 [35]

Native polystyrene, which is often used as a reversed-phase material, must be first rendered hydrophilic by one of various surface-coating techniques before used in other chromatographic methods [8]