glutathione therapy for parkinson& 39 Frontiers Repurposing the memory-promoting meclofenoxate hydrochloride

3404-A CONNECTIVE TISSUE GROWTH FACTOR IN LIVER SINUSOIDAL ENDOTHELIAL CELLS DRIVES LIVER FIBROGENESIS AND PORTAL HYPERTENSION IN CONGESTIVE HEPATOPATHY Seiya Kato 1 , Hayato Hikita 1 , Akira Doi 2 , Kazuhiro Murai 1 , Yuki Tahata 2 , Akira Nishio 3 , Kunimaro Furuta 1 , Takahiro Kodama 2 , Tomohide Tatsumi 2 and Tetsuo Takehara 2 , (1)Osaka University, Graduate School of Medicine, (2)Osaka University Graduate School of Medicine, (3)Osaka University Graduate School of Medicine, Bethesda, MD Background: The detail mechanism of pathogenesis in congestive hepatopathy, such as right-sided heart failure, post-Fontan surgery and Budd-Chiari syndrome, remains unclear

doi:10.1016/j.autrev.2020.102573 118

Other antioxidants According to the key role of oxidative stress in the pathogenesis of DE, many antioxidants targeting ROS production have shown the potential of DE treatment

[8] They found no acute toxicity at doses up to 10 mg/kg

There are studies to show that numerous cellular processes such as gene expression can influence changes in redox balance where moderate reactive oxygen and reactive nitrogen species production can lead to alterations in cellular and extracellular redox state [57]