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These findings support advancement into a pivotal Phase 3 trial in CSU and reinforce our confidence as we prepare to initiate a Phase 2b trial in food allergy by year-end

Recent data also indicate that the extent of mitochondrial protein release and DNA fragmentation could also dictate severity of liver injury in response to APAP between substrains of the common C57BL/6 mouse species used as an animal model of APAP-induced liver injury82

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doi: 10.1038/s41571-021-00521-0 66 CornishAJGruberAJKinnersleyBChubbDFrangouACaravagnaGet al

Its concentration is particularly high in mitochondria, where it protects respiratory chain complexes from oxidative stress (Wu et al., J Nutr 2004)