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Description

Results and discussion This section presents the results and discussion of the study, which focuses on predicting the solubility of rivaroxaban, a poorly water-soluble anticoagulant, in mixed solvent systems

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Indeed, if we replace the models of two c-METs from our structure of c-MET/HGF holo-complex to the N-terminus disordered c-MET, the distance between the two IPT2 domains is increased from 20 to 44 , suggesting that the compact c-MET is not in an ideal conformation for activation, which supports our hypothesis

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Crucially, no human trials define an optimal cycling schedule these are consensus patterns, not proven protocols, and should only be considered under a physicians supervision

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