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10.1016/j.jtbi.2022.111270 Summary Keywords climate change, weather, phenotypic plasticity, development, stochasticity Citation Burggren WW and Mendez-Sanchez JF (2023) Bet hedging against climate change in developing and adult animals: roles for stochastic gene expression, phenotypic plasticity, epigenetic inheritance and adaptation

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Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased