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In respect of physiological volumes of the brain fluids, V u,brain of 0.2 mL/g brain is the lowest possible value, which is equal to ISF volume, V brain,ISF (102), while V u,brain close to the 0.8 mL/g brain displays the water volume in the brain indicating an even distribution within the brain (103)

Keywords: vitamin C, ascorbic acid, enzymatic cofactor, antioxidant, pro-oxidant effect health, scurvy, cardiovascular diseases, cancer, infections, chronic diseases 1

In white adipose tissue, RES decreases adipogenesis and/or de novo lipogenesis, thereby reducing fat storage, and enhances the browning process, which is associated with increased energy expenditure

doi: 10.1007/s40263-024-01073-4

However, excessive cholesterol accumulation disrupts this equilibrium and contributes to metabolic disorders, including cardiovascular disease, type 2 diabetes mellitus (T2DM), and MASLD [18]