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Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer

While PROTACs can theoretically overcome resistance associated with conventional inhibitors, their efficacy in practice may be compromised by tumor immune evasion or the downregulation of E3 ligase expression

However, their prominence has also contributed to an overemphasis on RCTs as the only true evidence of causation, sometimes at the expense of other valuable study designs