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Substituting a helix-favouring alanine at that position is a potency modification of a kind long documented in the GRF structureactivity literature it raises GH-releasing potency in isolated pituitary cells, an assay that reflects receptor affinity rather than pharmacokinetics

Update 15 , 213227 (2008)

The histone deacetylase SIRT2 stabilizes Myc oncoproteins

"Cette molcule est un pseudopeptide, compose de trois acides amins : la glycine, la cystine et le glutamate

Subsequent research led to the development of related compounds with varying potency, receptor selectivity, and effects on other pituitary hormones