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[DOI] [PubMed] [Google Scholar] 639.Joshi MS, Ferguson TB, Jr, Han TH, Hyduke DR, Liao JC, Rassaf T, Bryan N, Feelisch M, Lancaster JR., Jr Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions

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For example, it has been shown that melanocyte-stimulating factors, such as -MSH, ET-1, or ACTH, can remain upregulated for several months to years following repeated UV exposure, long after visible pigmentation has faded 17

These are promising compounds, not proven medications, and anyone considering them should understand that distinction clearly