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When cells are exposed to oxidative and/or electrophilic stress, KEAP1 thiol residues are directly modified, which inactivates the ubiquitin E3 ligase activity of KEAP1-CUL3 complex, leading to stabilization of NRF2

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If you start at full dose and develop a headache, you cannot tell if the peptide caused it or if you would have had that headache anyway

et al., 2024) and activation-induced cell death (AICD) (Figure 6)