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Historical research on GHK-Cu's biological functions The review consolidates findings from laboratory studies, animal models, and human clinical trials spanning from the 1980s to 2018

The process of wound healing is intricate and cascaded, particularly in chronic wounds like severe burns and diabetic wounds, where unfavorable endogenous or external variables can impede the healing process by interfering with the regulation of inflammation [37]

Finally, there are also data showing that even though serum IGF-I is acutely increased following prednisolone, this is not the case in lymph-like tissue fluid (107), suggesting that glucocorticoids exert distinct, compartment-specific effects on IGF-I action

The researchers commented that these might include important systems, namely, dopamine-, NO-, prostaglandin-, somatosensory neuron-system, and more