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The cerebrovasculature is a very bioenergetically active tissue with capillary endothelial cells having been shown to possess five times more mitochondria than muscle cells (Oldendorf and Brown, 1975) and transport 10 times their weight in glucose each minute across the BBB, along with accomplishing other energetically costly cellular processes (Cunnane et al., 2011)

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StatPearls, Treasure Island (FL): StatPearls Publishing Copyright 2022, StatPearls Publishing LLC Sisson H (2015) Aspirating during the intramuscular injection procedure: a systematic literature review