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Plant Cell 10:461473 Mittler R, Herr EH, Orvar BL, Van Camp W, Willekens H, Inz D, Ellis BE (1999) Transgenic tobacco plants with reduced capability to detoxify reactive oxygen intermediates are hyperresponsive to pathogen infection

This affects blood flow and can lead to inflammation, causing symptoms like tiredness, memory problems, eye disease, hair loss, skin rashes, and blood issues

[4] showed that MT knockout in mice resulted in higher body weight during the early stages of life, with a greater potential for obesity when consuming a high-fat diet

Peitzsch, C., Tyutyunnykova, A., Pantel, K

Although ergothioneine is present in plants and animals, evidence for ergothioneine biosynthesis, to date, is limited to bacteria and fungi (Reference Jones, Doyle and Fitzpatrick9,Reference Stampfli, Blankenfeldt and Seebeck10)