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Endogenous GLP-1 is rapidly degraded primarily by dipeptidyl peptidase-4 (DPP-4), as well as neutral endopeptidase 24 } : CS1 maint: DOI inactive as of July 2026 (link) Journal of Diabetes

This interaction is mediated through the pathways of the nervous, immune, endocrine, and metabolic systems, playing a pivotal role in modulating states of anxiety, depression, and cognitive abilities, also impacts the initiation and advancement of neurodegenerative disorders, including Alzheimer's (107) and Parkinson's diseases (108), along with other pathological states (Figure 3)

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Tandon, M., Vemula, S

Localized heating alters ion permeability coefficients, as described by the Goldman-Hodgkin-Katz (GHK) equation (Equation 1), influencing membrane potential (Vm) and neuronal excitability