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Intradiscal injection of human recombinant BMP-4 does not reverse intervertebral disc degeneration induced by nuclectomy in sheep

Phytomedicine 139, 156538

Together, all of these data suggest that various stresses induce a generation of cytosolic H2O2, which in turn induces a MAPK cascade that subsequently stimulates expression of antioxidant genes, reducing H2O2 levels and restoring cellular homeostasis

Conversely, in the peripheral variant, histamine discharge from mast cells triggers the activation of itch receptors at the epidermal-dermal interface