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Oxidative Stress Explained Oxidative stress is when reactive oxygen species (ROS) and other free radicals overwhelm the antioxidant defenses that neutralize them

Studies indicate that NNMT is closely related to inflammatory status

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However, the miR-21 expression by the influence of curcumin is downregulated in hepatocellular cancer cells, which stimulates the expression of metalloproteinase-3 (TIMP3) and suppresses the GF-b1/smad3 signalling, resulting in the proliferating of cancer cells (Li et al., 2020)