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Cerebrospinal fluid glutamine levels are elevated in HE and correlate with disease severity, supporting a role for ammonia-related metabolism in its pathogenesis [26, 27]

Pancytopenia persisted, however, with a platelet nadir of 49,000/uL, and leucovorin (10 mg every 6 h) was added to her regimen on day 6

Journal of the International Society of Sports Nutrition 2013;10(5)

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Because citrulline is not metabolised by arginase in the liver and is efficiently converted to arginine in the kidneys, it may raise plasma arginine levels more effectively than arginine supplementation itself