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Furthermore, when combined with synephrine, which activates the 2-adrenergic receptor (2-AR) causing relaxation of bronchial smooth muscle, stachydrine enhances the bronchodilatory effect of synephrine, thus improving its efficacy in reducing airway spasms and supporting its use in asthma treatment (Shi et al., 2009)

however, its role in mediating therapeutic resistance in non-small cell lung cancer (NSCLC) remains incompletely understood

All authors critically revised the manuscript and agree to be fully accountable for ensuring the integrity and accuracy of the work and read and approved the final manuscript

Glaciol., 39, 4148, 2004

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