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For instance, Rappold and Tieu (2010) showed that MPTP is metabolized by the astrocytic monoamineoxidase-B (MAO-B) and converted to the toxic cation MPP + , which is extruded to the extracellular space through the organic cation transporter 3 (oct3) [6, 84]

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[DOI] [PubMed] [Google Scholar] 134.Verloop H., Dekkers O.M., Peeters R.P., Schoones J.W., Smit J.W

Figure 1 3.1 Couplings between cytokines, NOX, NO, Ca i 2+ and HIF-1 From the point of view of control theory, it is not easy to design a system that, when exposed to a variety of pathogens, excites itself to levels high enough to fight the pathogen, but not so high as to exceed the threshold of self-destruction