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TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

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Free Radical Res 55(1112):10481061 Lei L, Zhang F, Huang J, Yang X, Zhou X, Yan H, Chen C, Zheng S, Si L, Jose PA, Zeng C (2023) Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-B pathway

However, the recent findings that the genetic deletion of HIFs does not prevent cyst formation in Fh1-deficient mice 5 challenged their aetiological role in these tumours, indicating that other HIF-independent oncogenic pathways are involved

In our view, the communication and interaction between HIF-1 and BMAL1 require more precise exploration