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Negative effects on fertility may be related to the inhibition of GnRH expression, which promotes ovulation by stimulating LH expression

Rossman designed a randomized controlled trial involving 20 elderly people taking 20 mg/d Mito-Q or placebo for 6 weeks, and the results showed that the Mito-Q group was well tolerated without serious adverse events

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Then, we performed validation experiments via qRT-PCR for four hub genes ( Vwf , Vegfa , Kdr , Spp1 ) closely related to the PI3K/AKT signaling pathway, and the results aligned with the RNA-seq data

The percentage of SA--gal staining-positive cells was calculated in at least 3 random fields