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There are several reasons why this may happen

Biochim Biophys Acta BBAGen Subj 1830(5):32893303 Valko M, Jomova K, Rhodes CJ, Kua K, Muslek K (2016) Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

In this study, we used non-targeted metabolomics to identify changes in the aqueous humor of glaucoma patients

These included butanoate metabolism, lysine degradation, and arginine and proline metabolism

Beneficial commensals generally promote immune tolerance and help reinforce the intestinal barrier, whereas an overgrowth of pathogenic bacteria or loss of key symbionts (dysbiosis) can provoke systemic inflammation [34]