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Rare but serious# Systemic copper overload essentially only seen in people with undiagnosed Wilson's disease or other copper-handling disorders

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yet, the requirements for individual enzymes and their upstream regulators are not the same in all genetic (and perhaps environmental) conditions

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Based on such experiments, it may be concluded that the low catalase activity and high hydrogen peroxide production in Parkinson's disease might be due to (the indirect) inhibition of catalase expression by the -synuclein molecule

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