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FIGURE 2 Vitamin B12 Inhibited ER Stress Signaling Pathway Under chronic ER stress, the associated apoptosis may contribute to pathophysiological processes involved in a number of prevalent diseases, including neurodegenerative diseases, diabetes, atherosclerosis and renal disease (Figure 3AF, the levels of ER stress-related proteins (GRP78, IRE1, XBP-1, and CHOP) were significantly increased at 3 days and decreased after vitamin B12 treatment