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But one of the most dangerous ways it is released is the through the removal of mercury fillings

See p 83, 86 Page 252 and 253: Index and legal 12 Ni Sepharose Page 254 and 255: Phenyl Sepharose High Performan Page 256 and 257: CDM VIIISelect

To overcome such situations liver employs the efflux mechanisms, the efflux of DOX is achieved through from liver by ATP dependent ABC proteins (P-glycoprotein) which increase the efflux of the intracellular DOX and maintain the homeostasis