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In accordance with results from previous studies, we demonstrated that xCT and GPX4 mRNA and protein expression, both of which are key molecules involved in ferroptosis, were significantly decreased in cultured tubular epithelial cells exposed to TGF-1 and in the kidneys of STZ mice, suggesting that these changes may contribute to the decrease in glutathione concentration and the increase in lipid peroxidation

Chattrairat K, Yasui T, Suzuki S, et al

We reason that treatment with ENDO3 would recapitulate the Munc13-4-KO phenotype should the inhibitor operate through the inhibition of Munc13-4STX7 binding

Additionally, antioxidants can protect sperm DNA integrity, reducing fragmentation caused by ROS during sperm processing, which is crucial for successful fertilization and embryo development