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For example, tumor cells with mutations in the epidermal growth factor receptor (EGFR) are more dependent on cysteine, increasing their sensitivity to the inhibition of SLC7A11 and the depletion of GSH, which induces ferroptosis ( Figure 2 ) ( Figure 2 4.2 Inducing ferroptosis increases sensitivity to radiotherapy As the importance of ferroptosis in tumors is increasingly recognized, ferroptosis induction in tumor cells has become a hot topic in scientific research

4T1 cells were stained with 2,7-dichlorofluorescein diacetate (DCF-DA), a typical probe of ROS 40 , under different treatment conditions