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In plasma, MDD patients showed increased TRP degradation and reduced KYNA levels and neuroprotective ratios than healthy controls [37]

10.1016/S0369-8114(02)00290-0 51

Regulation of system x(c)(-)activity and expression in astrocytes by interleukin-1beta: implications for hypoxic neuronal injury

Over the years, a daunting task for researchers has been the identification of the complex set of conditions which govern the Substantia nigra microenvironment for transformation of -synuclein from a functional and grossly structureless chaperone to toxic cross- fibrils