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If effective, the therapy would work for individuals with any exon 51 mutation

Drake, Ph.D Linus Pauling Institute Oregon State University Updated in July 2013 by: Barbara Delage, Ph.D

Glutaminase inhibition then suppresses cancer cell growth, elevates intracellular ROS, and concurrently upregulates uridine phosphorylase 1 (UPP1), which promotes 5-FU conversion to its active form and thereby enhances 5-FU efficacy (171)