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G., Dai, F

Compared to Ad cells, significantly increased 13 C 3 -lactate-derived metabolites in AR cells included pyruvate, acetyl-CoA, TCA cycle intermediates (fold change from high to low: oxaloacetate, succinate, -ketoglutarate, malate, fumarate, isocitrate, and citrate), and TCA cycle-derived metabolites (glutamate, aspartate, and ribose-5-phosphate), indicating enhanced lactate uptake and oxidation as well as increased TCA metabolism (Fig

Brennan, A

[2] Examples of multienzyme complexes As noted above, especially in eukaryotes, multienzyme complexes, like multifunctional enzymes, are common in both anabolic and catabolic pathways, whereas few enzymes diffuse freely in solution

All currently available SLC7A11 inhibitors, including sulfasalazine and erastin, have either off-target effects or bioavailability issues