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We view it as a reliable, gentle staple of the medicine cabinetsomething that "just works" without much thought for what happens once it leaves the stomach

The authors also reported that mouse embryonic fibroblasts of PAD4 knockout mice showed increased FUS aggregation and sequestration into SGs compared with PAD4 overexpression cells, indicating that citrullination inhibits FUS phase separation 113

Deficiency leads to nerve damage (neuropathy), which presents as numbness, tingling, or weakness

Patients should be encouraged to consume B12-rich foods, including: Meat, particularly liver and kidney Fish and shellfish Dairy products (milk, cheese, yoghurt) Eggs Fortified breakfast cereals and plant-based milk alternatives For patients following plant-based diets, fortified foods and supplementation become essential, as vitamin B12 is naturally found almost exclusively in animal products

38 The release of lysosomal enzymes into the cytosol is dependent on the specific lysosomal enzyme cathepsin B