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Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype

doi: 10.1038/s41590-024-01756-6 303 VardjanNGabrijelMPotokarMSvajgerUKreftMJerasMet al

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AP-1 is not a single protein but a dimer composed of activating (c-Fos and c-Jun) and inhibitory (Fos-related antigen [Fra]-1 and 2) subunits (47)

Conversely, TLYYH intervention markedly suppressed potentially harmful genera, such as Helicobacter and Desulfovibrio