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Specifically, hepatoma cells with low expression of GOT2 showed a high dependence on Gln metabolism by increasing Gln metabolism, nucleotide synthesis, and glutathione synthesis to support cellular antioxidants (Fig

Early accumulation of ROS may be an important cause of -syn aggregation, and iron buildup could serve as an early marker of PD by inducing oxidative stress that promotes -syn aggregation

Hiplito A, Xavier R, Brito C, Toms A, Lemos I, Cabao LC, Silva F, Oliva A, Barral DC, Vicente JB, Gonalves LG, Pojo M, Serpa J (2024b) BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma

There were no significant differences between the treatment and placebo groups with regard to primary or secondary endpoints, and the results did not identify any clinical benefits of selenium supplementation in high-risk cardiac surgery patients

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