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Superoxide radical anion and hydrogen peroxide in vivo are mainly generated in the mitochondrial electron transport chain during the transition from state III to IV (Samartsev et al., 2020)

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High Intensity (HI 100Hz), Low Intensity (LI 50Hz), and Nave Control (NC Mock stimulation vs CON) groups were used to compare these effects on Nrf2-ARE binding, Keap1 protein content, and downstream gene and protein expression of Nrf2 target genes