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(1) ROS directly attacks the mitochondria of chondrocytes, causing leakage of the electron transport chain (ETC) and further generating superoxide anion (O ), which forms a vicious cycle, inducing collapse of mitochondrial membrane potential and ATP synthesis disorder

A score of 10 or higher on the PHQ-9 assessment indicates a significant level of depression, qualifying for higher CMI potential

DC, JY, XK, XW and YH participated in data analysis and manuscript editing

B12 supports normal metabolic processes, but it is not a stand-alone weight loss treatment

USADA is located in Colorado Springs, Colorado, and operates in the Mountain Time Zone