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Genetic animal models that manipulate the expression of proteins involved in dopamine homeostasis have provided key insight into the consequences of dysregulated dopamine

These research findings prove that exercise not only boosts physical fitness, but also, by promoting the levels of neurotrophic factors, helps PTSD patients recover from trauma-induced damage to the nervous system, thus boosting the restoration of the HPA axis and slowing down the long-term neuroendocrine influences of post-traumatic stress responses

But more aggressive treatment is not always more effective

IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections

Considering this context and the paucity of comparable studies our data corroborate and give additional insights to the recent literature pointing to a key role of TDP-43 mutations in the compromission of cell bioenergetics