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Glutathione combats this stress by donating electrons to neutralize free radicals

doi: 10.1038/s41467-023-36209-5 399 YehH.IkezuT

Immunotherapy of HBV-related advanced hepatocellular carcinoma with short-term HBV-specific TCR expressed T cells: results of dose escalation, phase I trial

Collectively, these results demonstrate that DLBCL cells, regardless of subtype, exhibit profound sensitivity to ferroptosis induction via small molecule GPX4 inhibition, and that this vulnerability is specific to malignant B-cells, supporting ferroptosis as a selective and mechanistically distinct strategy for therapeutic intervention in aggressive lymphomas