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A 2025 pilot study published in PubMed confirmed short-term tolerance in 2 participants at 20mg intravenously, though the sample size remains too limited for definitive safety conclusions

Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS

In fact, just ~ 41% of the variance in cognitive trajectory between individuals is ascribable to brain presence of A, tau or other neuropathologies 4,5,6