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Lactate also induces SMCT2 expression in CD4 + T cells, driving lactate uptake and increasing IL-17 production via PKM2/STAT3 signaling, suggesting that targeting SMCT2 could help alleviate chronic inflammatory disorders [120]

Table 1 Mechanism of QUE enhancing the sensitivity of different tumor cell lines to 5-FU

On the other hand, various risk factors such as unhealthy dietary regimens, physical inactivity, smoking, and alcohol abuse play a major role in the development and acceleration of cardiovascular diseases (80)